Improving Consumption

The information systems (IS) research relevance debate was sparked by concerns that the research community is delivering products that are only sometimes considered useful. Symptoms of the problem include the marketability of IS graduates, our failure to lead industry, the proliferation of journals and conferences with overlapping themes, and a rewards system that is geared towards outputs. Relevance, in my view, is a function of addressing the right problem and packaging the results in a manner suitable for consumption. My recommendations therefore include: identifying the fundamental and applied areas; recognizing our limitations in these areas; providing research summaries; clarifying the research channels by avoiding overlaps in conferences and journals; and altering the rewards and control systems such that they are biased towards contribution to the discipline

Connecting to the Next Generation Mobile Desktop

Mobile phones have evolved over the years from a plain device that allowed voice communication to the present day smart phones that are capable of variety of tasks. Much touted smart phone lacks some of the rudimentary business as well as other functions that are available in a traditional laptop/desktop. This article proposes a new system called Next Generation Mobile Desktop (NGMD) that provides desktop equivalent functions on a functional mobile phone. Proposed NGMD leverage some of the emerging technologies to offer enhanced services to the user. This article discusses some of the existing as well as new mobile technologies and then proposes the architecture for the NGMD. This article also discusses some of the services offered by NGMD and provides illustrative examples of them. We believe NGMD capable phones would dominate the corporate market and free up the user from carrying multiple devices while on the road

Envisioning the Next Generation Cellular Client

The cellular revolution has been accompanied by a gradual evolution in functionality. The Motorola handie-talkie introduced in the early 1940‟s was a five pound behemoth that barely worked. Contemporary phones have become ubiquitous devices that are outfitted with camera, video, GPS, internet and e-mail. Fourth generation phones are expected to provide high speed internet access for data as well as multi-media through protocols that subsume existing standards. Beyond this, the capabilities of 4G phones have not been spelled out in detail. In this paper we outline our vision of a feature rich next generation phone that is backed up by an infrastructure of service offerings

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. For example, a key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process versus those that measure fl ux through the autophagy pathway (i.e., the complete process including the amount and rate of cargo sequestered and degraded). In particular, a block in macroautophagy that results in autophagosome accumulation must be differentiated from stimuli that increase autophagic activity, defi ned as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (inmost higher eukaryotes and some protists such as Dictyostelium ) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the fi eld understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. It is worth emphasizing here that lysosomal digestion is a stage of autophagy and evaluating its competence is a crucial part of the evaluation of autophagic flux, or complete autophagy. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. Along these lines, because of the potential for pleiotropic effects due to blocking autophagy through genetic manipulation it is imperative to delete or knock down more than one autophagy-related gene. In addition, some individual Atg proteins, or groups of proteins, are involved in other cellular pathways so not all Atg proteins can be used as a specific marker for an autophagic process. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field

The immuno-oncological challenge of COVID-19

International audienceCoronavirus disease 2019 (COVID-19) and its causative virus, SARS-CoV-2, pose considerable challenges for the management of oncology patients. COVID-19 presents as a particularly severe respiratory and systemic infection in aging and immunosuppressed individuals, including patients with cancer. Moreover, severe COVID-19 is linked to an inflammatory burst and lymphopenia, which may aggravate cancer prognosis. Here we discuss why those with cancer are at higher risk of severe COVID-19, describe immune responses that confer protective or adverse reactions to this disease and indicate which antineoplastic therapies may either increase COVID-19 vulnerability or have a dual therapeutic effect on cancer and COVID-19. Zitvogel and colleagues discuss the interplay between cancer and COVID-19 with respect to patient risk and prognosis, immune responses and potential therapies